Simple partial seizures aggravated or induced by benzodiazepine injection

Corrigendum to “Simple partial seizures aggravated or induced by benzodiazepine injection” [Seizure 41 (2016) 6–8]

Effect of intracerebroventricular injection of aqueous extract and essential oil of Pulicaria gnaphalodes on PTZ-induced seizures in male rat

Introduction: Pulicaria gnaphalodes contains terpenoids and flavonoids. Referring to the role of benzodiazepine (BZD) receptor ligands as drug candidates in the treatment of epilepsy, anxiety and sleep disturbances, and since natural flavonoids are among these candidates and hold promise as BZD receptor ligands, this research was done to assess the effects of aqueous extract and essential oi...

Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABAA Receptors

Background: Despite introduction of modern antiepileptic drugs, 30% of epileptic patients are still drug resistant. Remarkable three-dimensional spatial structure of AdCA, yet the simplicity of the molecule, makes AdCA a promising lead compound. Methods: Sedative/motor impairment and 24-h mortality rate of AdCA were determined in mice. Impact of AdCA on (1) threshold and occurrence of clonic se...

Effect of intracerebroventricular injection of olive leaf extract on PTZ-induced seizures in male rats

Introduction: Olive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ. Methods: In this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg ...

Effect of intracerebroventricular injection of COX-1 inhibitor (ketoprofen) on PTZ-induced seizures in male rat

Introduction: Ketoprofen is an NSAID and selective COX-1 inhibitor. In our previous study the role of flunixin meglumine, a nonselective COX inhibitor was studied on seizure and its anticonvulsant effects were confirmed. Therefore this research is performed to assess the role of a selective COX-1 inhibitor, ketoprofen in treatment of seizures induced by PTZ. Methods: In this research, male ...